Synergizing our Cores and Projects to enhance scientific progress and knowledge

Our multi-disciplinary, team-based research is comprised of three Cores and two Projects, working together to understand the multiple nodes of tau metabolism and pathobiology.

How the Projects & Cores Interact

Our FTD CWOW is structured to enable researchers to systematically identify, test, and share novel insights across multiple institutions. By synergizing our research efforts and creating opportunities for substantive scientific interactions, the Center creates an efficient pipeline for assessing the functional impact of variation in tau metabolism genes that may promote risk for tauopathy.

Our unique team of experts in distinct, complementary disciplines will allow for highly synergistic interactions, where the whole will be much greater than the sum of the parts.


CWOW Organizational Figure


#1: Mutants, PTMs, Structures
#2: SNPs, Risks, Functional Data
#3: Structures, Fragments
#4: SNPs, Risks, Functionality

CWOW Cores

CWOW Projects


This U54 A138178 grant is funded by the National Institutes of Health (NIH), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS)