Publications

Impacting science through the discovery of tau machinery

Highlighted Resource Publications

 

TOPICS

Tau Chaperones, Targeting, and Proteolysis

Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases
Molecular Neurodegeneration, May 2023. See Article
Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW

Tuberous sclerosis complex is associated with a novel human tauopathy
Acta Neuropathologica, December 2022. See Article
Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, Miller BL, Kao AW, Seeley WW

TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy
Science Advances, November 2021. See Article
Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL, Kao AW

Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration
Molecular Neurodegeneration, August 2021. See Article
Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation
Frontiers in Neurology, January 2021. See Article
Alquezar C, Arya S, Kao AW

Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia
Acta Neuropathologica, November 2017. See Article
Olney NT, Alquezar C, Ramos EM, Nana AL, Fong JC, Karydas AM, Taylor JB, Stephens ML, Argouarch AR, Van Berlo VA, Dokuru DR, Sherr EH, Jicha GA, Dillon WP, Desikan RS, De May M, Seeley WW, Coppola G, Miller BL, Kao AW

Progranulin, lysosome regulation and neurodegenerative disease
Nature Reviews Neuroscience, June 2017. See Article
Kao AW, McKay A, Singh PP, Brunet A, Huang EJ

Macromolecular Structure

Cryo-EM reveals how Hsp90 and FKBP immunophilins co-regulate the glucocorticoid receptor
Nat Struct Mol Biol, Dec 2023. See Article
Noddings CM, Johnson JL, Agard DA

Structure of Hsp90-Hsp70-Hop-GR reveals the Hsp90 client-loading mechanism
Nature, January 2022. See Article
Wang RY, Noddings CM, Kirschke E, Myasnikov AG, Johnson JL, Agard DA

Structure of Hsp90-p23-GR reveals the Hsp90 client-remodelling mechanism
Nature, January 2022. See Article
Noddings CM, Wang RY, Johnson JL, Agard DA

Hsp70 chaperone blocks α-synuclein oligomer formation via a novel engagement mechanism
Journal of Biological Chemistry, March 2021. See Article
Tao J, Berthet A, Citron YR, Tsiolaki PL, Stanley R, Gestwicki JE, Agard DA, McConlogue L

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
BMC Biology, January 2020. See Article
Joshi A, Dai L, Liu Y, Lee J, Ghahhari NM, Segala G, Beebe K, Jenkins LM, Lyons GC, Bernasconi L, Tsai FTF, Agard DA, Neckers L, Picard D

Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity
Journal of Biological Chemistry, August 2018. See Article
Elnatan D, Agard DA

Tau Half-life and Secretion

Mutant tau and stress lead to downregulation of long noncoding RNA, SNHG8
Mol Psychiatry, November 2023. See Article
Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM

Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutation
Acta Neuropathologica, June 2023. See Article
Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, Cantoni C, De Feo L, Ghezzi L, Minaya MA, Renganathan A, Cashikar AG, Satoh JI, Beatty W, Iyer AK, Cella M, Raskind WH, Piccio L, Karch CM

Defective proteostasis in induced pluripotent stem cell models of frontotemporal lobar degeneration
Translational Psychiatry, December 2022. See Article
Mahali S, Martinez R, King M, Verbeck A, Harari O, Benitez BA, Horie K, Sato C, Temple S, Karch CM.

Astrocytic 4R tau expression drives astrocyte reactivity and dysfunction
JCI Insight, December 2021. See Article
Ezerskiy LA, Schoch KM, Sato C, Beltcheva M, Horie K, Rigo F, Martynowicz R, Karch CM, Bateman RJ, Miller TM

ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids
Cell, August 2021. See Article
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S.

Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice
Nature Communications, April 2021. See Article
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM.

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading
Molecular Psychiatry, October 2021. See Article
Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H.

A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies
Stem Cell Reports, November 2019. See Article
Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S (Tau Consortium Stem Cell Group)

Genomics and Transcriptomics

Expansion of highly interferon-responsive T cells in early-onset Alzheimer's disease
Alzheimers Dement, June 2024. See Article
Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Oddi AP, Geier EG, Miller BL, Rabinovici GD, Yokoyama JS

Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
Alzheimers Dement, September 2023. See Article
Mantyh WG, Cochran JN, Taylor JW, Broce IJ, Geier EG, Bonham LW, Anderson AG, Sirkis DW, Joie R, Iaccarino L, Chaudhary K, Edwards L, Strom A, Grant H, Allen IE, Miller ZA, Gorno-Tempini ML, Kramer JH, Miller BL, Desikan RS, Rabinovici GD, Yokoyama JS

Role for cell death pathway in Alzheimer's disease
Science, September 2023. See Article
Sirkis DW, Yokoyama JS

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy
Genome Med, July 2023. See Article
Sirkis DW, Warly Solsberg C, Johnson TP, Bonham LW, Sturm VE, Lee SE, Rankin KP, Rosen HJ, Boxer AL, Seeley WW, Miller BL, Geier EG, Yokoyama JS

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease
JAMA Neurology, October 2021. See Article
Davis EJ, Solsberg CW, White CC, Miñones-Moyano E, Sirota M, Chibnik L, Bennett DA, De Jager PL, Yokoyama JS, Dubal DB

SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan
Nature Communications, January 2021. See Article
Johnson AE, Orr BO, Fetter RD, Moughamian AJ, Primeaux LA, Geier EG, Yokoyama JS, Miller BL, Davis GW

Brain volumetric deficits in MAPT mutation carriers: a multisite study
Annals of Clinical and Translational Neurology, January 2021. See Article
Chu SA, Flagan TM, Staffaroni AM, Jiskoot LC, Deng J, Spina S, Zhang L, Sturm VE, Yokoyama JS, Seeley WW, Papma JM, Geschwind DH, Rosen HJ, Boeve BF, Boxer AL, Heuer HW, Forsberg LK, Brushaber DE, Grossman M, Coppola G, Dickerson BC, Bordelon YM, Faber K, Feldman HH, Fields JA, Fong JC, Foroud T, Gavrilova RH, Ghoshal N, Graff-Radford NR, Hsiung GR, Huey ED, Irwin DJ, Kantarci K, Kaufer DI, Karydas AM, Knopman DS, Kornak J, Kramer JH, Kukull WA, Lapid MI, Litvan I, Mackenzie IRA, Mendez MF, Miller BL, Onyike CU, Pantelyat AY, Rademakers R, Marisa Ramos E, Roberson ED, Carmela Tartaglia M, Tatton NA, Toga AW, Vetor A, Weintraub S, Wong B, Wszolek ZK; ARTFL/LEFFTDS Consortium, Van Swieten JC, Lee SE

Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia
Acta Neuropathologica, January 2019. See Article
Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS

Non-coding and Loss-of-Function Coding Variants in TET2 are Associated with Multiple Neurodegenerative Diseases
American Journal of Human Genetics, May 2020. See Article
Cochran JN, Geier EG, Bonham LW, Newberry JS, Amaral MD, Thompson ML, Lasseigne BN, Karydas AM, Roberson ED, Cooper GM, Rabinovici GD, Miller BL, Myers RM, Yokoyama JS (Alzheimer’s Disease Neuroimaging Initiative)