Improving our understanding of FTLD-tau pathobiology by engaging a diverse transdisciplinary team of scientists.
Our FTD Center Without Walls (CWOW) goal is to improve our understanding of the pathobiological mechanisms underlying FTLD-tau.
Thank you to our funders: the National Institutes of Health (NIH), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS).
Our Aims
Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less
Marie Skłodowska-Curie
First woman to win a Nobel Prize — Physics, 1903; First person to win two Nobel Prizes — Chemistry, 1911
- To elucidate the genes, molecules, and pathways that regulate tau metabolism
- To determine the impact of disease-associated mutations and variants on FTLD-tau pathobiology
Our Goals
- To understand the normal process of tau metabolism as a series of decisions made at regulatory nodes
- To identify and test the functional relevance of genetic variants in MAPT and other tau-metabolism genes
- To create a Tau Metabolism and Variant Database (TMVdb) providing functional annotation to MAPT and other tau-metabolism genes
- To create a Tau Polygenic Risk Score (TPRS) to stratify genetic risk for tauopathy
